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Flavay® can stimulate the immune response to help normalize the balance of chemicals in the body that control pain and inflammation and normalize joint function.
Flavay® has been licensed and sold in France for treating inflammation and edema (swelling) since 1950 and it is now available in the United States as a dietary supplement. This highly specialized, nutritional complex of molecules has been isolated from natural extracts and extensively tested and examined clinically for biological antioxidant protection, collagen strengthening, tissue rebuilding, and other health producing outcomes.
Scientific research shows several ways that Flavay® can stimulate the immune response to help normalize the balance of chemicals in the body that control pain and inflammation and normalize joint function.
The "Radical Scavenger" as a Natural Anti-Inflammatory
Inflammation is caused by the overproduction of free radicals in a specific area of the body. We now know that antioxidants work together to defeat free radicals and inhibit the biological pathway that triggers inflammation, and Flavay® is particularly effective as an anti-inflammatory.
Flavay® can selectively bind to the connective tissue of joints, preventing inflammation and lessening pain. One of the very first benefits observed and studied Dr. Jack Masquelier, in as early as 1947, was the anti-inflammatory effect of Flavay®.
Research demonstrates that Flavay® inhibits the release and synthesis of histamine (which produces accelerated blood flow, dilates capillaries and increases their permeability, thereby leaking plasma into surrounding tissue), a key factor in the promotion of inflammation.
Studies demonstrate that the anti-histamine action of Flavay® is obtained through inhibiting the activity of the enzyme histidine decarboxylase. Dr. Masqueliers research has been confirmed by German studies which show that Flavay® may lower the production of histamine with as much as 86% inhibition of histidine decarboxylase.
Flavay® also neutralizes free radicals that promote swelling and cause inflammation. When joints become arthritic, they become inflamed and enlarged, interfering with the normal flow of blood. For example, when you bend an arthritic knee, you cut off blood flow to the area which sets into motion of a chain of events that will lead to a burst of free radicals when the blood flow returns (known as "reperfusion injury"). When you release the knee, a proliferation of free radicals causes the area to become even more inflamed, contributing to the degeneration of the joint, which becomes more swollen and worn down. Reducing free radicals eases the swelling associated with inflammation and improves arthritic condition. Research has shown that a free radical called "superoxide" is involved in the inflammation of arthritis and experiments demonstrate that Flavay® quenches the superoxide free radicals. In fact, Flavay® is scientifically proven to act as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation. But that's not all it does.
Reducing Edema (Swelling) by Strengthening Capillary Walls
Edema is an uncomfortable condition and can be both painful and dangerous. Swollen and painful legs and ankles, puffiness of the eyes and an overall bloated look and feel are examples of edema. It involves the leakage of blood serum into surrounding tissues and Flavay® has shown that it can reduce this leakage by strengthening capillary walls.
Italian scientists from the University of Florence studied the effect of Flavay® on venous congestion (edema) in the legs. The study involved 40 subjects consisting of 13 men and 27 women between the ages of 34 and 74. The subjects were randomly divided into two groups. One group received a placebo and the other group received 300 mg of Flavay® daily for 60 days.
All of those taking the Flavay® had relief from at least some of the symptoms. After 30 days, the pain was totally relieved in in 38 percent of those taking Flavay®, the swelling disappeared in 26 percent (the circumference of the legs was measured above the ankle), and 11 percent experienced a decrease in the feeling of heaviness in their lower limbs. After 60 days, the pain was totally relieved in 67 percent of those taking Flavay®, the swelling disappeared in 63 percent, and the decrease in heaviness jumped to 33 percent.
Recovery from Injuries
Research has shown that Flavay’s® ability to strengthen vascular walls may help the body to repair injuries faster. In an Australian study conducted on two groups of soccer players that had sustained injuries, those that consumed Flavay® for ten days following their injuries experienced significantly less swelling than those who did not and, in some of those taking Flavay®, the swelling had completely disappeared. Other research has demonstrated the ways in which Flavay® may actually inhibit inflammation including double-blind studies conducted in France which showed that Flavay® can reduce postoperative inflammation.
Reducing Collagen (Cartilage) Degradation
Arthritis is an umbrella term for more than 100 different conditions that produce either inflammation of connective tissue (joints and tendons) or degeneration of the articular (joint) cartilage, a wearing down of the protective covering that cushions the ends of bones, allowing bones to rub together without causing damage to the joints.
Collagen is required for the normal functioning of the joints, healthy cartilage and bones, smooth gliding surfaces, synovial fluid, normal joint spaces and normal soft tissues surrounding the joints. Collagen is the building block of connective tissue, veins, arteries, ligaments and tendons, and every tissue and organ.
The nutrients in Flavay® can be considered as 'collagen vitamins' because they partake in the biosynthesis of collagen and prevent its destruction. Through synergistic action with vitamin C, Flavay® strengthens and rebuilds the bodys natural collagen proteins and has the remarkable ability to reactivate damaged collagen and elastin. Research has demonstrated that Flavay® binds to collagen fibers and realigns them to a more youthful, undamaged form. (The same research also established that common bioflavonoids are completely inactive in this respect.) Flavay® improves the beneficial cross-linking between the amino acids of the fibers that give collagen its flexibility and strength while preventing the undesirable cross-linking between amino acids that weakens collagen. Laboratory tests have demonstrated Flavay’s® ability to reduce degradation of elastin fibers by up to 70 percent.
Nitric Oxide Toxicity and Chronic Inflammation
Contemporary research shows that elevated levels of nitric oxide (sometimes referred to as "NO") appear to contribute to arthritis and other disorders associated to abnormal immune or inflammatory responses. In the case of arthritis, nitric oxide has been implicated in the destruction of the pericellular and extracellular matrix of cartilage in arthritis.
When joints become arthritic, they become inflamed and enlarged, interfering with the normal flow of blood. For example, when you bend an arthritic knee, you cut off blood flow to the area which sets into motion of a chain of events that will lead to a burst of free radicals when the blood flow returns (known as "reperfusion injury"). When you release the knee, a proliferation of free radicals causes the area to become even more inflamed, contributing to the degeneration of the joint, which becomes more swollen and worn down.
It's long been recognized that nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, excessive amounts of nitric oxide can restrict blood flow and promote production of more free radicals, including the dangerous peroxynitrate.
Flavay® can significantly scavenge nitric oxide radicals. However, as we'll discuss next, your body needs a certain amount of nitric oxide in order to maintain good health. Nitric oxide is paradoxical. Under normal health conditions, nitric oxide can act as an anti-inflammatory. But to an already inflamed area, nitric oxide can wreak havoc by causing even more inflammation. The key, therefore, to normalizing joint function is to maintain the optimum balance of this double-edged sword, nitric oxide.
Flavay® and the Nitric Oxide Connection
Nitric oxide is a colorless gas produced by many different cells in the body that, depending on the situation, can be very good or very bad. Nitric oxide plays several important roles in the body:
But nitric oxide can be very destructive under other circumstances:
The real trouble starts when nitric oxide encounters the superoxide free radical and becomes peroxynitrate, which destroys antioxidants like glutathione, vitamin E and common flavonoids, and damages proteins in the body. As long as nitric oxide is produced in the right amount, it remains friendly. But if nitric oxide is overproduced, the effect can be very toxic. Research demonstrates that Flavay® can help to maintain the optimal level of nitric oxide by helping the body to produce adequate levels—and to neutralize this free radical where it does harm.
Flavay's® strong antioxidant power acts as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation and the degradation of collagen.
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